Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study

被引：57

作者：

Breitner, John ^{[1
,2
]}

Baker, Laura ^{[3
,4
]}

Drye, Lea ^{[5
]}

Evans, Denis ^{[6
,14
]}

Lyketsos, Constantine ^{[7
]}

Ryan, Laurie ^{[8
]}

Zandi, Peter ^{[5
]}

Saucedo, Hector Hernandez

Anau, Jane

Cholerton, Brenna

Kramer, Kirise

Casper, Anne Shanldin ^{[5
]}

Meinert, Curtis ^{[5
]}

Martin, Barbara ^{[5
]}

Jenkins, Gabrielle ^{[5
]}

McCaffrey, Lee ^{[5
]}

Meinert, Jill ^{[5
]}

Vaidya, Vijay ^{[5
]}

Abuja, Alka ^{[5
]}

May, Pat ^{[5
]}

Ashe, Karen ^{[9
]}

Steinberg, Martin ^{[7
]}

Brandt, Jason ^{[7
]}

Pedroso, Julia J. ^{[7
]}

Bergey, Alyssa ^{[7
]}

Gogel, Carol ^{[7
]}

Smith, Lynn ^{[7
]}

Kraus, Jennifer ^{[7
]}

Stern, Robert A. ^{[10
]}

Green, Robert C. ^{[10
]}

Gavett, Brandon ^{[10
]}

Mwicigi, Jane ^{[10
]}

Baldwin, Lorraine ^{[10
]}

McGowan, Theresa ^{[10
]}

Johnson, Patricia ^{[10
]}

Qiu, Wendy ^{[10
]}

Frederick, Jamie ^{[10
]}

Raghavan, Sumati ^{[10
]}

Rossi, Carol ^{[10
]}

Mandell, Alan ^{[10
]}

Dinizo, Daniella ^{[10
]}

Roth, Mary Tara ^{[10
]}

Porsteinsson, Anton ^{[11
]}

Ismail, M. Saleem ^{[11
]}

Weber, Miriam ^{[11
]}

Brand, Connie ^{[11
]}

Richard, Jennifer ^{[11
]}

Stear, Kelly ^{[11
]}

Schepp, Sue ^{[11
]}

Cosman, Kelly ^{[11
]}

机构：

[1] Douglas Mental Hlth Univ Inst, Ctr Studies Prevent Alzheimers Dis, Montreal, PQ, Canada

[2] McGill Univ, Montreal, PQ, Canada

[3] Veteran Affairs Puget Sound Hlth Care Syst, Seattle, WA USA

[4] Univ Washington, Sch Med, Seattle, WA USA

[5] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[6] Rush Univ, Med Ctr, Chicago, IL 60612 USA

[7] Johns Hopkins Sch Med, Baltimore, MD USA

[8] NIA, Bethesda, MD 20892 USA

[9] N Bud Grossman Ctr Memory Res & Care, Minneapolis, MN USA

[10] Boston Univ, Sch Med, Boston, MA 02118 USA

[11] Univ Rochester, Sch Med, Rochester, NY 14627 USA

[12] Sun Hlth Res Inst, Sun City, AZ USA

[13] Roskamp Inst Memory Clin, Tampa, FL USA

[14] Rush Presbyterian St Lukes Med Ctr, Chicago, IL USA

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 02期

关键词：

Prevention; Clinical trial; Alzheimer's disease; Cognitive function; Nonsteroidal anti-inflammatory drug; Naproxen; Celecoxib; NSAID USE; DECLINE; DRUGS; CELECOXIB; NAPROXEN; ASSOCIATION; POPULATION; VALIDATION; ASPIRIN; SCALE;

D O I：

10.1016/j.jalz.2014.03.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: The Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) and Follow-up Study (ADAPT-FS) examined effects of naproxen and celecoxib on cognition in the elderly. We report here results describing trajectories of cognitive evaluation test scores. Methods: A total of 2356 participants completed baseline and at least one follow-up cognitive evaluation between 2001 and 2004. Study treatments were discontinued in 2004, but participants were followed until 2007. A total of 1537 participants were reevaluated in 2010 to 2011. Outcomes include seven cognitive evaluations administered yearly in person in ADAPT and three of these evaluations that were administered by telephone near the end of ADAPT and again in ADAPT-FS. Results: There were no important differences over time by treatment group on any ADAPT cognitive measure, a global composite, or the three cognitive measures reassessed in ADAPT-FS by telephone. Conclusions: Treatment for 1 to 3 years with naproxen or celecoxib did not protect against cognitive decline in older adults with a family history of AD. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：216 / 225

页数：10

共 29 条

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[Anonymous], 2013, ALZHEIMERS DEMENT

[2]

[Anonymous], 1991, Clin Neuropsychol

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