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Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations

被引：7
作者：
Merali, S
Chin, K
Grady, RW
Clarkson, AB
机构：
[1] NYU,SCH MED,DEPT MED & MOLEC PARASITOL,NEW YORK,NY 10016
[2] CORNELL UNIV MED COLL,DEPT PEDIAT,NEW YORK,NY 10021
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 05期
关键词：
D O I：
10.1128/AAC.40.5.1298
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of greater than or equal to 1.5 mu g ml(-1) eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS-associated P. carinii pneumonia.
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收藏
页码：1298 / 1300
页数：3
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