Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations

被引：7

作者：

Merali, S

Chin, K

Grady, RW

Clarkson, AB

机构：

[1] NYU,SCH MED,DEPT MED & MOLEC PARASITOL,NEW YORK,NY 10016

[2] CORNELL UNIV MED COLL,DEPT PEDIAT,NEW YORK,NY 10021

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 05期

关键词：

D O I：

10.1128/AAC.40.5.1298

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of greater than or equal to 1.5 mu g ml(-1) eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS-associated P. carinii pneumonia.

引用

页码：1298 / 1300

页数：3

共 18 条

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