Emerging synthetic approaches for protein-polymer conjugations

被引：174

作者：

Broyer, Rebecca M.

Grover, Gregory N.

Maynard, Heather D. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA 90095 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 08期

基金：

美国国家科学基金会;

关键词：

TRANSFER RADICAL POLYMERIZATION; IN-SITU GROWTH; STIMULI-RESPONSIVE POLYMERS; UNNATURAL AMINO-ACIDS; RAFT POLYMERIZATION; POLYETHYLENE-GLYCOL; HETEROTELECHELIC POLYMERS; FUNCTIONALIZED POLYMERS; BLOCK-COPOLYMERS; PEGYLATED INTERFERON-ALPHA-2B;

D O I：

10.1039/c0cc04062b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Protein-polymer conjugates are important in diverse fields including drug delivery, biotechnology, and nanotechnology. This feature article highlights recent advances in the synthesis and application of protein-polymer conjugates by controlled radical polymerization techniques. Special emphasis on new applications of the materials, particularly in biomedicine, is provided.

引用

收藏

页码：2212 / 2226

页数：15

相关论文

共 110 条

[1] PREPARATION AND PROPERTIES OF POLYETHYLENE GLYCOL TRYPSIN ADDUCTS [J].

ABUCHOWSKI, A ;

DAVIS, FF .

BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 578 (01) :41-46

[2] Stimuli responsive polymers for biomedical applications [J].

Alarcón, CDH ;

Pennadam, S ;

Alexander, C .

CHEMICAL SOCIETY REVIEWS, 2005, 34 (03) :276-285

[3] β-sheet side chain polymers synthesized by atom-transfer radical polymerization [J].

Ayres, L ;

Adams, PHHM ;

Löwik, DWPM ;

van Hest, JCM .

BIOMACROMOLECULES, 2005, 6 (02) :825-831

[4] Elastin-based side-chain polymers synthesized by ATRP [J].

Ayres, L ;

Vos, MRJ ;

Adams, PJHM ;

Shklyarevskiy, IO ;

van Hest, JCM .

MACROMOLECULES, 2003, 36 (16) :5967-5973

[5] Protein Chemical Modification on Endogenous Amino Acids [J].

Basle, Emmanuel ;

Joubert, Nicolas ;

Pucheault, Mathieu .

CHEMISTRY & BIOLOGY, 2010, 17 (03) :213-227

[6] Synthesis of Semitelechelic Maleimide Poly(PEGA) for Protein Conjugation By RAFT Polymerization [J].

Bays, Emmanuelle ;

Tao, Lei ;

Chang, Chien-Wen ;

Maynard, Heather D. .

BIOMACROMOLECULES, 2009, 10 (07) :1777-1781

[7] Functionalized micellar assemblies prepared via block copolymers synthesized by living free radical polymerization upon peptide-loaded resins [J].

Becker, ML ;

Liu, JQ ;

Wooley, KL .

BIOMACROMOLECULES, 2005, 6 (01) :220-228

[8] Peptide-polymer bioconjugates:: hybrid block copolymers generated via living radical polymerizations from resin-supported peptides [J].

Becker, ML ;

Liu, JQ ;

Wooley, KL .

CHEMICAL COMMUNICATIONS, 2003, (02) :180-181

[9] One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP [J].

Bontempo, D ;

Li, RC ;

Ly, T ;

Brubaker, CE ;

Maynard, HD .

CHEMICAL COMMUNICATIONS, 2005, (37) :4702-4704

[10] Streptavidin as a macroinitiator for polymerization: In situ protein-polymer conjugate formation [J].

Bontempo, D ;

Maynard, HD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (18) :6508-6509

← 1 2 3 4 5 6 7 8 9 10 →