DNA cleavage by photogenerated Rh2(O2CCH3)4(H2O)2+

被引：53

作者：

Fu, PKL ^{[1
]}

Bradley, PM ^{[1
]}

Turro, C ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

INORGANIC CHEMISTRY | 2001年 / 40卷 / 11期

关键词：

D O I：

10.1021/ic010118w

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Irradiation of Rh-2(O2CCH3)(4)(H2O)(2) with visible light in the presence of electron accepters results in the formation of the oxidized complex, Rh-2(O2CCH3)(4)- (H2O)(2)(+). Photogenerated Rh-2(O2CCH3)(4)(H2O)(2)(+) is able to cleave plasmid DNA, whereas the Rh-2(O2CCH3)(4)(L)(2)(+) complexes with nonlabile axial ligands, L, such as py (pyridine) and PPh3 (triphenylphosphine), do not cleave the double helix. Rh-2(O2CCH3)(4)(H2O)(2)(+) [GRAPHICS]

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页码：2476 / +

页数：3

相关论文

共 25 条

[1] AXIAL-LIGAND SUBSTITUTION-REACTIONS OF DIRHODIUM(II) TETRAACETATE WITH PHOSPHINES AND PHOSPHITES IN ACETONITRILE [J].

AQUINO, MAS ;

MACARTNEY, DH .

INORGANIC CHEMISTRY, 1987, 26 (16) :2696-2699

[2] LIGAND SUBSTITUTION-REACTIONS OF DIRHODIUM(II) TETRAACETATE WITH WATER-SOLUBLE PHOSPHINES [J].

AQUINO, MAS ;

MACARTNEY, DH .

INORGANIC CHEMISTRY, 1988, 27 (16) :2868-2872

[3] Evidence for binding of dirhodium bis-acetate units to adjacent GG and AA sites on single-stranded DNA [J].

Asara, JM ;

Hess, JS ;

Lozada, E ;

Dunbar, KR ;

Allison, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (01) :8-13

[4] Studies of antibacterial activity of binuclear rhodium(II) complexes with heterocyclic nitrogen ligands [J].

Bien, M ;

Pruchnik, FP ;

Seniuk, A ;

Lachowicz, TM ;

Jakimowicz, P .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1999, 73 (1-2) :49-55

[5] Excited-state properties of Rh2(O2CCH3)4(L)2 (L = CH3OH, THF, PPh3, py) [J].

Bradley, PM ;

Bursten, BE ;

Turro, C .

INORGANIC CHEMISTRY, 2001, 40 (06) :1376-1379

[6]

BRADLEY PM, IN PRESS COMMENTS IN

[7] Measurement of local DNA reorganization on the picosecond and nanosecond time scales [J].

Brauns, EB ;

Madaras, ML ;

Coleman, RS ;

Murphy, CJ ;

Berg, MA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (50) :11644-11649

[8] Reactions of DNA purines with dirhodium formamidinate compounds that display antitumor behavior [J].

Catalan, KV ;

Hess, JS ;

Maloney, MM ;

Mindiola, DJ ;

Ward, DL ;

Dunbar, KR .

INORGANIC CHEMISTRY, 1999, 38 (17) :3904-3913

[9] A novel dirhodium compound with neutral, bridging 9-ethyladenine ligands [J].

Catalan, KV ;

Mindiola, DJ ;

Ward, DL ;

Dunbar, KR .

INORGANIC CHEMISTRY, 1997, 36 (11) :2458-2460

[10] Guanine radical cations are precursors of 7,8-dihydro-8-oxo-2'-deoxyguanosine but are not precursors of immediate strand breaks in DNA [J].

Cullis, PM ;

Malone, ME ;

MersonDavies, LA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (12) :2775-2781