[1] Kyoto Katsura Hosp, Div Resp, Nishikyo Ku, Kyoto 6158256, Japan
[2] Shiga Univ Med Sci, Dept Cardiovasc & Resp Med, Otsu, Shiga, Japan
[3] Gallen Res, Manchester, Lancs, England
[4] Kyoto Univ, Grad Sch Med, Dept Resp Med, Kyoto, Japan
[5] Kyoto Univ, Fac Med, Dept Pharmacol, Kyoto, Japan