A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

被引：421

作者：

Abnet, Christian C. ^{[1
]}

Freedman, Neal D. ^{[1
]}

Hu, Nan ^{[1
]}

Wang, Zhaoming ^{[1
,2
]}

Yu, Kai ^{[1
]}

Shu, Xiao-Ou ^{[3
,4
]}

Yuan, Jian-Min ^{[5
]}

Zheng, Wei ^{[3
,4
]}

Dawsey, Sanford M. ^{[1
]}

Dong, Linda M. ^{[1
]}

Lee, Maxwell P. ^{[6
]}

Ding, Ti ^{[7
]}

Qiao, You-Lin ^{[8
]}

Gao, Yu-Tang ^{[9
]}

Koh, Woon-Puay ^{[10
]}

Xiang, Yong-Bing ^{[9
]}

Tang, Ze-Zhong ^{[7
]}

Fan, Jin-Hu ^{[8
]}

Wang, Chaoyu ^{[1
]}

Wheeler, William ^{[11
]}

Gail, Mitchell H. ^{[1
]}

Yeager, Meredith ^{[1
,2
]}

Yuenger, Jeff ^{[1
,2
]}

Hutchinson, Amy ^{[1
,2
]}

Jacobs, Kevin B. ^{[1
,2
]}

Giffen, Carol A. ^{[11
]}

Burdett, Laurie ^{[1
,2
]}

Fraumeni, Joseph F., Jr. ^{[1
]}

Tucker, Margaret A. ^{[1
]}

Chow, Wong-Ho ^{[1
]}

Goldstein, Alisa M. ^{[1
]}

Chanock, Stephen J. ^{[1
]}

Taylor, Philip R. ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[2] SAIC Frederick Inc, NCI Frederick, Core Genotyping Facil, Frederick, MD USA

[3] Vanderbilt Univ, Dept Med, Nashville, TN USA

[4] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[5] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[6] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[7] Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China

[8] Chinese Acad Med Sci, Dept Epidemiol, Canc Inst Hosp, Beijing 100037, Peoples R China

[9] Shanghai Canc Inst, Shanghai, Peoples R China

[10] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Epidemiol & Publ Hlth, Singapore 117595, Singapore

[11] Informat Management Serv Inc, Silver Spring, MD USA

来源：

NATURE GENETICS | 2010年 / 42卷 / 09期

关键词：

GENOME-WIDE ASSOCIATION; CANCER; CHINA; RISK; MUTATIONS; VARIANT; TRACT; CHEK2;

D O I：

10.1038/ng.649

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combined analysis of 2,240 gastric cancer cases, 2,115 ESCC cases and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.

引用

页码：764 / U51

页数：5

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