The architectural organization and mechanistic function of group II intron structural elements

被引:124
作者
Qin, PZ
Pyle, AM
机构
[1] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA
[2] Columbia Univ, Dept Appl Phys, Howard Hughes Med Inst, New York, NY 10032 USA
关键词
D O I
10.1016/S0959-440X(98)80062-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Group II introns are large, self-splicing RNAs and mobile genetic elements that provide good model systems for studies of RNA folding. The structures and mechanistic functions of individual domains are being elucidated, and long-range tertiary interactions between the domains are being identified, thus helping to define the three-dimensional architecture of the intron.
引用
收藏
页码:301 / 308
页数:8
相关论文
共 58 条
[11]   FREQUENT USE OF THE SAME TERTIARY MOTIF BY SELF-FOLDING RNAS [J].
COSTA, M ;
MICHEL, F .
EMBO JOURNAL, 1995, 14 (06) :1276-1285
[12]   A group II self-splicing intron from the brown alga Pylaiella littoralis is active at unusually low magnesium concentrations and forms populations of molecules with a uniform conformation [J].
Costa, M ;
Fontaine, JM ;
Loiseaux-de Goër, S ;
Michel, F .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 274 (03) :353-364
[13]   Multiple tertiary interactions involving domain II of group II self-splicing introns [J].
Costa, M ;
Deme, E ;
Jacquier, A ;
Michel, F .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 267 (03) :520-536
[14]   Two competing pathways for self-splicing by group II introns: A quantitative analysis of in vitro reaction rates and products [J].
Daniels, DL ;
Michels, WJ ;
Pyle, AM .
JOURNAL OF MOLECULAR BIOLOGY, 1996, 256 (01) :31-49
[15]   DOMAIN-5 INTERACTS WITH DOMAIN-6 AND INFLUENCES THE 2ND TRANSESTERIFICATION REACTION OF GROUP-II INTRON SELF-SPLICING [J].
DIBHAJJ, SD ;
BOULANGER, SC ;
HEBBAR, SK ;
PEEBLES, CL ;
FRANZEN, JS ;
PERLMAN, PS .
NUCLEIC ACIDS RESEARCH, 1993, 21 (08) :1797-1804
[16]   Mobility of yeast mitochondrial group II introns: Engineering a new site specificity and retrohoming via full reverse splicing [J].
Eskes, R ;
Yang, JA ;
Lambowitz, AM ;
Perlman, PS .
CELL, 1997, 88 (06) :865-874
[17]   THE MITOCHONDRIAL LSU RDNA OF THE BROWN ALGA PYLAIELLA-LITTORALIS REVEALS ALPHA-PROTEOBACTERIAL FEATURES AND IS SPLIT BY 4 GROUP-IIB-INTRONS WITH AN ATYPICAL PHYLOGENY [J].
FONTAINE, JM ;
ROUSVOAL, S ;
LEBLANC, C ;
KLOAREG, B ;
LOISEAUXDEGOER, S .
JOURNAL OF MOLECULAR BIOLOGY, 1995, 251 (03) :378-389
[18]   The reverse-transcriptase-like proteins encoded by group II introns in the mitochondrial genome of the brown alga Pylaiella littoralis belong to two different lineages which apparently coevolved with the group II ribosyme lineages [J].
Fontaine, JM ;
Goux, D ;
Kloareg, B ;
LoiseauxdeGoer, S .
JOURNAL OF MOLECULAR EVOLUTION, 1997, 44 (01) :33-42
[19]   KINETIC-ANALYSIS OF THE 5' SPLICE JUNCTION HYDROLYSIS OF A GROUP-II INTRON PROMOTED BY DOMAIN-5 [J].
FRANZEN, JS ;
ZHANG, MC ;
PEEBLES, CL .
NUCLEIC ACIDS RESEARCH, 1993, 21 (03) :627-634
[20]  
Gaur RK, 1997, RNA, V3, P861