Rynaxypyr™:: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

被引：464

作者：

Lahm, George P. ^{[1
]}

Stevenson, Thomas M. ^{[1
]}

Selby, Thomas P. ^{[1
]}

Freudenberger, John H. ^{[1
]}

Cordova, Daniel ^{[1
]}

Flexner, Lindsey ^{[1
]}

Bellin, Cheryl A. ^{[1
]}

Dubas, Christine M. ^{[1
]}

Smith, Ben K. ^{[1
]}

Hughes, Kenneth A. ^{[1
]}

Hollingshaus, J. Gary ^{[1
]}

Clark, Christopher E. ^{[1
]}

Benner, Eric A. ^{[1
]}

机构：

[1] Stine Haskell Res Ctr, DuPont Crop Protection, Newark, DE 19711 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 22期

关键词：

Rynaxypyr (TM); ryanodine; receptor; insecticide;

D O I：

10.1016/j.bmcl.2007.09.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rynaxypyr (TM) is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6274 / 6279

页数：6

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