Immune regulation by novel costimulatory molecules

被引：110

作者：

Dong, C ^{[1
]}

Nurieva, RI ^{[1
]}

Prasad, DVR ^{[1
]}

机构：

[1] Univ Washington, Dept Immunol, Sch Med, Seattle, WA 98195 USA

来源：

IMMUNOLOGIC RESEARCH | 2003年 / 28卷 / 01期

基金：

美国国家卫生研究院;

关键词：

helper T-lymphocytes; costimulation; inducible costimulator; B7-H3; Th1/Th2; cytokines; autoimmune diseases;

D O I：

10.1385/IR:28:1:39

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

CD4 helper T (Th)-cells and the cytokines that they produce play essential regulatory roles in immune and autoimmune responses. Th activation and differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are important in maintaining the threshold of T-cell activation. ICOS and PD-1 are novel costimualatory receptors expressed on activated T-cells. B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function.

引用

页码：39 / 48

页数：10

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