The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour

被引：86

作者：

Abildgaard, Anders ^{[1
,2
]}

Elfving, Betina ^{[1
]}

Hokland, Marianne ^{[3
]}

Wegener, Gregers ^{[1
,4
]}

Lund, Sten ^{[5
]}

机构：

[1] Aarhus Univ, Translat Neuropsychiat Unit, Risskov, Denmark

[2] Aarhus Univ Hosp, Dept Clin Biochem, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark

[3] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[4] North West Univ, Ctr Excellence Pharmaceut Sci, Potchefstroom Campus, Potchefstroom, South Africa

[5] Aarhus Univ Hosp, Dept Med Endocrinol MEA, Aarhus, Denmark

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 124卷 / 04期

关键词：

Blood glucose; insulin; depression; diabetes mellitus; xenobiotics; TYPE-2; DIABETES-MELLITUS; INSULIN SENSITIVITY; GUT MICROBIOME; ANIMAL-MODEL; RISK-FACTOR; DEPRESSION; STRESS; METAANALYSIS; RESISTANCE; MELATONIN;

D O I：

10.1080/13813455.2017.1398262

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA). Objective: We therefore wanted to study the isolated effect of IPA on behaviour and glucose metabolism in rats. Methods: Male Sprague-Dawley rats were fed control or IPA-enriched diet for six weeks (n = 12 per group) and assessed in the elevated plus maze, open field and forced swim test. Blood glucose, metabolic hormones and the white blood cell (WBC) composition were analysed. Results: IPA (mean intake 27.3 mg/kg/day) significantly lowered fasting blood glucose level by 0.42 mM (95% CI 0.11-0.73). Similarly, fasting plasma insulin levels and the homeostatic model assessment (HOMA) index of insulin resistance were reduced, whereas plasma metabolic hormones, behaviour and WBC composition remained unaffected by IPA. Conclusions: Our findings highlight IPA as a promising candidate for treatment of metabolic disorders associated with insulin resistance.

引用

页码：306 / 312

页数：7

共 53 条

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