Development of indole-3-propionic acid (OXIGON™) for Alzheimer's disease

被引：138

作者：

Bendheim, PE ^{[1
]}

Poeggeler, B

Neria, E

Ziv, V

Pappolla, MA

Chain, DG

机构：

[1] Mindset Biopharmaceut Ltd, Jerusalem, Israel

[2] Univ Gottingen, D-3400 Gottingen, Germany

[3] Univ S Alabama, Mobile, AL 36688 USA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2002年 / 19卷 / 1-2期

关键词：

Alzheimer's disease; beta-amyloid; oxidative stress; indole-3-propionic acid;

D O I：

10.1007/s12031-002-0036-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON(TM)) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.

引用

页码：213 / 217

页数：5

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