Phosphoinositide 3-kinase-dependent activation of Rac

被引：272

作者：

Welch, HCE ^{[1
]}

Coadwell, WJ

Stephens, LR

Hawkins, PT

机构：

[1] Babraham Inst, Signaling Programme, Inositide Lab, Cambridge CB2 4AT, England

[2] Babraham Inst, Bioinformat Grp, Cambridge CB2 4AT, England

来源：

FEBS LETTERS | 2003年 / 546卷 / 01期

关键词：

Rae; GTPase; phosphoinositide; 3-kinase; guanine-nucleotide exchange factor; signalling;

D O I：

10.1016/S0014-5793(03)00454-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The monomeric GTPase Rac and the lipid kinase phosphoinositide 3-kinase (PI3K) are intracellular signalling enzymes that each regulate a huge range of cellular functions. Their signalling pathways overlap. Several pathways lead from PI3K activation via the production of the lipid second messenger phosphatidylinositol (3,4,5)-triphosphate (PtdIns(3,4,5)P-3) to the activation of guanine-nucleotide exchange factors (GEFs) that activate Rac. Vice versa, Rac can also stimulate the activation of PI3K, although the mechanism for this is unclear. We review here the evidence that links PI3K and Rac signalling pathways. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：93 / 97

页数：5

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