An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves

被引：68

作者：

Gelens, E

Smeets, L

Sliedregt, LAJM

van Steen, BJ

Kruse, CG

Leurs, R

Orru, RVA ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Fac Exact Sci, Dept Chem, Amsterdam, Netherlands

[2] Solvay Pharmaceut Res Labs, Weesp, Netherlands

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 21期

关键词：

amides; synthesis; solvent free; microwave;

D O I：

10.1016/j.tetlet.2005.03.146

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides were obtained in high ee or de. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：3751 / 3754

页数：4

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