3-acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation

被引：25

作者：

Lin, RH ^{[1
]}

Lu, YH ^{[1
]}

Wetter, SK ^{[1
]}

Connolly, PJ ^{[1
]}

Turchi, IJ ^{[1
]}

Murray, WV ^{[1
]}

Emanuel, SL ^{[1
]}

Gruninger, RH ^{[1
]}

Fuentes-Pesquera, AR ^{[1
]}

Adams, M ^{[1
]}

Pandey, N ^{[1
]}

Moreno-Mazza, S ^{[1
]}

Middleton, SA ^{[1
]}

Jolliffe, LK ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Drug Discovery, Raritan, NJ 08869 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 09期

关键词：

D O I：

10.1016/j.bmcl.2005.03.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells. © 2005 Elsevier Ltd. All rights reserved.

引用

页码：2221 / 2224

页数：4

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