Cerebellar output: motor and cognitive channels

被引:144
作者
Middleton, FA
Strick, PL
机构
[1] Vet Adm Med Ctr, Res Serv 151S, Syracuse, NY 13210 USA
[2] SUNY Hlth Sci Ctr, Dept Neurosurg, Syracuse, NY 13210 USA
[3] SUNY Hlth Sci Ctr, Dept Neurosci Physiol, Syracuse, NY 13210 USA
关键词
D O I
10.1016/S1364-6613(98)01220-0
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The input to the cerebellum has long been known to originate from widespread regions of the cerebral cortex including the frontal, parietal and temporal lobes. The output of the cerebellum, however, was thought to project mainly to the primary motor cortex. Recent anatomical observations have challenged this view. It is now apparent that cerebellar output goes to multiple cortical areas, including not: only the primary motor cortex, but also areas of premotor and prefrontal cortex. In fact, there is growing evidence that each of the areas of cerebral cortex that project to the cerebellum is also the target of cerebellar output. The cerebellar output to individual cortical areas originates from distinct clusters of neurons in the deep nuclei which we have termed 'output channels'. The individual output channels to the cortical areas we have examined display little or no overlap. Physiological recordings in awake trained primates indicate that neurons in different output channels appear to be involved in distinct aspects of behavior, and in both motor and cognitive functions. These observations indicate that the cerebellar influence on the cerebral cortex is more than previously recognized.
引用
收藏
页码:348 / 354
页数:7
相关论文
共 62 条
[1]   CEREBROCEREBELLAR COMMUNICATION SYSTEMS [J].
ALLEN, GI ;
TSUKAHARA, N .
PHYSIOLOGICAL REVIEWS, 1974, 54 (04) :957-1006
[2]   Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry [J].
Andreasen, NC ;
OLeary, DS ;
Cizadlo, T ;
Arndt, S ;
Rezai, K ;
Ponto, LLB ;
Watkins, GL ;
Hichwa, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9985-9990
[3]   Recent advances in defining the neuropathology of schizophrenia [J].
Arnold, SE ;
Trojanowski, JQ .
ACTA NEUROPATHOLOGICA, 1996, 92 (03) :217-231
[4]   DISTRIBUTION OF CEREBELLAR TERMINATIONS AND THEIR RELATION TO OTHER AFFERENT TERMINATIONS IN THE VENTRAL LATERAL THALAMIC REGION OF THE MONKEY [J].
ASANUMA, C ;
THACH, WT ;
JONES, EG .
BRAIN RESEARCH REVIEWS, 1983, 5 (03) :237-265
[5]   Neural systems engaged by planning: A PET study of the Tower of London task [J].
Baker, SC ;
Rogers, RD ;
Owen, AM ;
Frith, CD ;
Dolan, RJ ;
Frackowiak, RSJ ;
Robbins, TW .
NEUROPSYCHOLOGIA, 1996, 34 (06) :515-526
[6]   HISTOANATOMIC OBSERVATIONS OF THE BRAIN IN EARLY INFANTILE-AUTISM [J].
BAUMAN, M ;
KEMPER, TL .
NEUROLOGY, 1985, 35 (06) :866-874
[7]   ROLE OF THE CEREBELLUM IN COMPLEX HUMAN-BEHAVIOR [J].
BOTEZ, MI ;
BOTEZ, T ;
ELIE, R ;
ATTIG, E .
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1989, 10 (03) :291-300
[8]   CORTICOPONTINE PROJECTION IN RHESUS-MONKEY - ORIGIN AND PRINCIPLES OF ORGANIZATION [J].
BRODAL, P .
BRAIN, 1978, 101 (JUN) :251-283
[9]   CONDITIONAL ASSOCIATIVE LEARNING IS IMPAIRED IN CEREBELLAR DISEASE IN HUMANS [J].
CANAVAN, AGM ;
SPRENGELMEYER, R ;
DIENER, HC ;
HOMBERG, V .
BEHAVIORAL NEUROSCIENCE, 1994, 108 (03) :475-485
[10]   Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism [J].
Courchesne, E .
CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (02) :269-278