共 196 条
Organization of multiprotein complexes at cell-cell junctions
被引:113
作者:

Ebnet, Klaus
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机构:
Univ Munster, Ctr Mol Biol & Inflammat ZMBE, Inst Med Biochem, Munster, Germany Univ Munster, Ctr Mol Biol & Inflammat ZMBE, Inst Med Biochem, Munster, Germany
机构:
[1] Univ Munster, Ctr Mol Biol & Inflammat ZMBE, Inst Med Biochem, Munster, Germany
关键词:
adherens junction;
tight junction;
cell polarity;
cell-cell adhesion;
protein complexes;
JAM;
PAR proteins;
D O I:
10.1007/s00418-008-0418-7
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The formation of stable cell-cell contacts is required for the generation of barrier-forming sheets of epithelial and endothelial cells. During various physiological processes like tissue development, wound healing or tumorigenesis, cellular junctions are reorganized to allow the release or the incorporation of individual cells. Cell-cell contact formation is regulated by multiprotein complexes which are localized at specific structures along the lateral cell junctions like the tight junctions and adherens junctions and which are targeted to these site through their association with cell adhesion molecules. Recent evidence indicates that several major protein complexes exist which have distinct functions during junction formation. However, this evidence also indicates that their composition is dynamic and subject to changes depending on the state of junction maturation. Thus, cell-cell contact formation and integrity is regulated by a complex network of protein complexes. Imbalancing this network by oncogenic proteins or pathogens results in barrier breakdown and eventually in cancer. Here, I will review the molecular organization of the major multiprotein complexes at junctions of epithelial cells and discuss their function in cell-cell contact formation and maintenance.
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页码:1 / 20
页数:20
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