Nanoscale Plasmonic Interferometers for Multispectral, High-Throughput Biochemical Sensing

被引：148

作者：

Feng, Jing ^{[1
]}

Siu, Vince S. ^{[1
]}

Roelke, Alec ^{[1
]}

Mehta, Vihang ^{[1
]}

Rhieu, Steve Y. ^{[1
]}

Palmore, G. Tayhas R. ^{[1
]}

Pacifici, Domenico ^{[1
]}

机构：

[1] Brown Univ, Sch Engn, Providence, RI 02912 USA

来源：

NANO LETTERS | 2012年 / 12卷 / 02期

基金：

美国国家科学基金会;

关键词：

Plasmonic interferometers; surface plasmon polariton (SPP); nanoslits; nanogrooves; focused ion beam (FIB) milling; biosensor; glucose sensor; ENHANCED RAMAN-SCATTERING; OPTICAL-TRANSMISSION; SURFACE; ULTRASMALL; ARRAYS; DNA; NANOPARTICLES; SENSITIVITY; EXCITATION; SENSORS;

D O I：

10.1021/nl203325s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we report the design, fabrication, and characterization of novel biochemical sensors consisting of nanoscale grooves and slits milled in a metal film to form two-arm, three-beam, planar plasmonic interferometers. By integrating thousands of plasmonic interferometers per square millimeter with a microfluidic system, we demonstrate a sensor able to detect physiological concentrations of glucose in water over a broad wavelength range (400-800 nm). A wavelength sensitivity between 370 and 630 nm/RIU (RIU, refractive index units), a relative intensity change between similar to 10(3) and 10(6) %/RIU, and a resolution of similar to 3 x 10(-7) in refractive index change were experimentally measured using typical sensing volumes as low as 20 fL. These results show that multispectral plasmonic interferometry is a promising approach for the development of high-throughput, real-time, and extremely compact biochemical sensors.

引用

页码：602 / 609

页数：8

共 60 条

[1] High-Throughput Nanofabrication of Infrared Plasmonic Nanoantenna Arrays for Vibrational Nanospectroscopy [J].