Amphiphilic carborane-containing diblock copolymers

被引：32

作者：

Simon, Yoan C. ^{[1
]}

Ohm, Christian ^{[1
]}

Zimny, Melanie J. ^{[1
]}

Coughlin, E. Bryan ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA

来源：

MACROMOLECULES | 2007年 / 40卷 / 16期

关键词：

D O I：

10.1021/ma0709093

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A boron-containing monomer based on an oxonorbornene-functionalized o-carborane and its subsequent ring-opening metathesis polymerization to obtain low-polydispersity (PDI) high molecular-weight carborane-based polymers was synthesized. The formation of amphiphilic block copolymers was demonstrated by sequential monomer addition followed by deprotonation of the second block to generate the amphiphilic copolymers. The solution studies in water using Dynamic Light Scattering (DLS) show that these polymers aggregate due to the formation of micelles that constitute corona and the carborane containing blocks. The aggregates of block copolymers are found to have an average hydrodynamic radius of 41 nm. The features of polymer drugs and efficacy of boron neutron capture therapy of cancer (BNCT) are combined to form a newly synthesized amphiphilic polymer that is used in high boron content micelles of BNCT.

引用

页码：5628 / 5630

页数：3

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