Production of a hypoglycemic, extracellular polysaccharide from the submerged culture of the mushroom, Phellinus linteus

被引:102
作者
Kim, DH [1 ]
Yang, BK [1 ]
Jeong, SC [1 ]
Park, JB [1 ]
Cho, SP [1 ]
Das, S [1 ]
Yun, JW [1 ]
Song, CH [1 ]
机构
[1] Taegu Univ, Dept Biotechnol, Kyungsan 712714, Kyungbuk, South Korea
关键词
extracellular polysaccharide; hypoglycemic effect; mushroom; Phellinus linteus; submerged mycelial culture;
D O I
10.1023/A:1010312513878
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Mycelial growth and extracellular polysaccharide production of Phellinus linteus were optimal at pH 5 and 25 degreesC. Maximum biomass production (14.2 g l(-1)) was after 15 d of cultivation, whereas, extracellular polysaccharide was maximal (3.5 g l(-1)) after 21 d. The hypoglycemic effect of the polysaccharide, investigated in streptozotocin-induced diabetic rats, decreased plasma glucose, total cholesterol and triacylglycerol concentrations by 49%, 32%, and 28%, respectively, and aspartate aminotransferase activity by 20%. The results indicate the potential of this polysaccharide to prevent hyperglycemia in diabetic patients.
引用
收藏
页码:513 / 517
页数:5
相关论文
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[11]  
Van Horn L., 1996, HDB DIABETES MED NUT HDB DIABETES MED NUT, P336