A mouse atlas of gene expression: Large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells

被引:91
作者
Siddiqui, AS
Khattra, J
Delaney, AD
Zhao, YJ
Astell, C
Asano, J
Babakaiff, R
Barber, S
Beland, J
Bohacec, S
Brown-John, M
Chand, S
Charest, D
Charters, AM
Cullum, R
Dhalla, N
Featherstone, R
Gerhard, DS
Hoffman, B
Holt, RA
Hou, J
Kuo, BYL
Lee, LLC
Lee, S
Leung, D
Ma, K
Matsuo, C
Mayo, M
McDonald, H
Prabhu, AI
Pandoh, P
Riggins, GJ
de Algara, TR
Rupert, JL
Smailus, D
Stott, J
Tsai, M
Varhol, R
Vrljicak, P
Wong, D
Wu, MK
Xie, YY
Yang, G
Zhang, I
Hirst, M
Jones, SJM
Helgason, CD
Simpson, EM
Hoodless, PA
Marra, MA
机构
[1] British Columbia Canc Agcy, Gen Sci Ctr, Vancouver, BC V5Z 4S6, Canada
[2] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 4S6, Canada
[3] British Columbia Canc Agcy, British Columbia Canc Res Ctr, Vancouver, BC V5Z 4S6, Canada
[4] British Columbia Res Inst Childrens & Womens Hlth, Ctr Mol Med & Therapeut, Vancouver, BC V6H 3N1, Canada
[5] NCI, Off Canc Gen, NIH, Bethesda, MD 20892 USA
[6] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21287 USA
[7] Univ British Columbia, Dept Med Genet, Vancouver, BC V6T 1Z4, Canada
[8] Univ British Columbia, Sch Human Kinet, Vancouver, BC V6T 1Z4, Canada
关键词
alternative transcripts; development; serial analysis of gene expression;
D O I
10.1073/pnas.0509455102
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We analyzed 8.55 million LongSAGE tags generated from 72 libraries. Each LongSAGE library was prepared from a different mouse tissue. Analysis of the data revealed extensive overlap with existing gene data sets and evidence for the existence of approximate to 24,000 previously undescribed genomic loci. The visual cortex, pancreas, mammary gland, preimplantation embryo, and placenta contain the largest number of differentially expressed transcripts, 25% of which are previously undescribed loci.
引用
收藏
页码:18485 / 18490
页数:6
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