AMPK and raptor: Matching cell growth to energy supply

被引：111

作者：

Hardie, D. Grahame ^{[1
]}

机构：

[1] Univ Dundee, Coll Life Sci, Div Mol Physiol, Dundee DD1 5EH, Scotland

来源：

MOLECULAR CELL | 2008年 / 30卷 / 03期

关键词：

D O I：

10.1016/j.molcel.2008.04.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：263 / 265

页数：3

共 10 条

[1] Defining the role of mTOR in cancer [J].

Guertin, David A. ;

Sabatini, David M. .

CANCER CELL, 2007, 12 (01) :9-22

[2] AMPK phosphorylation of raptor mediates a metabolic checkpoint [J].

Gwinn, Dana M. ;

Shackelford, David B. ;

Egan, Daniel F. ;

Mihaylova, Maria M. ;

Mery, Annabelle ;

Vasquez, Debbie S. ;

Turk, Benjamin E. ;

Shaw, Reuben J. .

MOLECULAR CELL, 2008, 30 (02) :214-226

[3] Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity [J].

Hahn-Windgassen, A ;

Nogueira, V ;

Chen, CC ;

Skeen, JE ;

Sonenberg, N ;

Hay, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (37) :32081-32089

[4] AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy [J].

Hardie, D. Grahame .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (10) :774-785

[5]

HUANG X, 2008, IN PRESS BIOCH J

[6] TSC2 mediates cellular energy response to control cell growth and survival [J].

Inoki, K ;

Zhu, TQ ;

Guan, KL .

CELL, 2003, 115 (05) :577-590

[7] Control of p70 ribosornal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes [J].

Krause, U ;

Bertrand, L ;

Hue, L .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (15) :3751-3759

[8] PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase [J].

Sancak, Yasemin ;

Thoreen, Carson C. ;

Peterson, Timothy R. ;

Lindquist, Robert A. ;

Kang, Seong A. ;

Spooner, Eric ;

Carr, Steven A. ;

Sabatini, David M. .

MOLECULAR CELL, 2007, 25 (06) :903-915

[9] Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate [J].

Scott, JW ;

Norman, DG ;

Hawley, SA ;

Kontogiannis, L ;

Hardie, DG .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 317 (02) :309-323

[10]

Wullschleger S, 2006, CELL, V124, P471, DOI 10.1016/j.cell.2006.01.016

← 1 →