Expression of cyclooxygenase-2 in breast carcinogenesis and its relation to HER-2/neu and p53 protein expression in invasive ductal carcinoma

被引：22

作者：

Cho, M. H. ^{[1
,2
]}

Yoon, J. H. ^{[1
,2
]}

Jaegal, Y. J. ^{[1
,2
]}

Choi, Y. D. ^{[3
]}

Lee, J. S. ^{[3
]}

Lee, J. H. ^{[3
]}

Nam, J. H. ^{[3
]}

Choi, C. ^{[3
]}

Lee, M. C. ^{[3
]}

Park, C. S. ^{[3
]}

Juhng, S. Woo ^{[3
]}

Min, K. W. ^{[4
]}

机构：

[1] Chonnam Natl Univ, Sch Med, Dept Surg, Kwangju 501746, South Korea

[2] Res Inst Med Sci, Kwangju 501746, South Korea

[3] Chonnam Natl Univ, Med Sch & Res Med Sci, Dept Pathol, Kwangju 501746, South Korea

[4] Deaconess Hosp, Dept Pathol, Oklahoma City, OK 73112 USA

来源：

BREAST | 2006年 / 15卷 / 03期

关键词：

breast; carcinogenesis; COX-2; p53; HER-2/neu;

D O I：

10.1016/j.breast.2005.06.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The purpose of this study was to evaluate cyclooxygenase-2 (COX-2) expression in the successive steps of breast carcinogenesis and to determine its correlation with HER-2/neu and p53 expression in invasive ductal carcinomas of the breast. Immunohistochemical staining with anti-COX-2 antibody was performed in normal breast tissue, usual hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma. Expression of COX-2 in invasive ductal carcinoma was correlated with immunohistochemical expression of HER-2/neu and p53 protein. COX-2 expression was found to be progressively elevated along the continuum from normal breast tissue to invasive ductal carcinoma (P < 0.001). COX-2 expression significantly correlated with p53 and HER-2/neu protein expression (P < 0.05 and P < 0.001). On multivariate analysis, only TNM stage and elevated COX-2 expression correlated with survival. Our results suggest that COX-2 may be involved in the carcinogenesis of the breast and may be an independent prognostic indicator in patients with invasive ductal carcinoma. HER-2/neu and p53 are likely to be involved in the regulation of COX-2 expression in invasive ductal carcinomas of the breast. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：390 / 398

页数：9

共 32 条

[1]

[Anonymous], 2002, AJCC cancer staging manual, P223, DOI [10.1007/978-1-4757-3656-4, DOI 10.1007/978-1-4757-3656-4]

[2]

IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN IN MAMMARY-CARCINOMA - AN IMPORTANT NEW INDEPENDENT INDICATOR OF PROGNOSIS [J].

BARNES, DM ;

DUBLIN, EA ;

FISHER, CJ ;

LEVISON, DA ;

MILLIS, RR .

HUMAN PATHOLOGY, 1993, 24 (05) :469-476

[3]

COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ [J].

Boland, GP ;

Butt, IS ;

Prasad, R ;

Knox, WF ;

Bundred, NJ .

BRITISH JOURNAL OF CANCER, 2004, 90 (02) :423-429

[4]

Cyclo-oxygenase inhibition reduces tumour growth and metastasis in an orthotopic model of breast cancer [J].

Connolly, EM ;

Harmey, JH ;

O'Grady, T ;

Foley, D ;

Roche-Nagle, G ;

Kay, E ;

Bouchier-Hayes, DJ .

BRITISH JOURNAL OF CANCER, 2002, 87 (02) :231-237

[5]

Connolly JL, 1996, HUM PATHOL, V27, P220

[6]

Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer [J].

Costa, C ;

Soares, R ;

Reis-Filho, JS ;

Leitao, D ;

Amendoeira, I ;

Schmitt, FC .

JOURNAL OF CLINICAL PATHOLOGY, 2002, 55 (06) :429-434

[7]

Davies G, 2003, CLIN CANCER RES, V9, P2651

[8]

Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma [J].

Denkert, C ;

Winzer, KJ ;

Müller, BM ;

Weichert, W ;

Pest, S ;

Köbel, M ;

Kristiansen, G ;

Reles, A ;

Siegert, A ;

Guski, H ;

Hauptmann, S .

CANCER, 2003, 97 (12) :2978-2987

[9]

Cyclooxygenase in biology and disease [J].

Dubois, RN ;

Abramson, SB ;

Crofford, L ;

Gupta, RA ;

Simon, LS ;

Van De Putte, LBA ;

Lipsky, PE .

FASEB JOURNAL, 1998, 12 (12) :1063-1073

[10]

Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma [J].

Gallo, O ;

Schiavone, N ;

Papucci, L ;

Sardi, I ;

Magnelli, L ;

Franchi, A ;

Masini, E ;

Capaccioli, S .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (02) :723-732

← 1 2 3 4 →