The domains of death: evolution of the apoptosis machinery

被引：332

作者：

Aravind, L ^{[1
]}

Dixit, VM

Koonin, EV

机构：

[1] NIH, NCBI, Natl Lib Med, Bethesda, MD 20894 USA

[2] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA

[3] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 02期

关键词：

D O I：

10.1016/S0968-0004(98)01341-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent progress in research into programmed cell death has resulted in the identification of the principal protein domains involved in this process. The evolution of many of these domains can be traced back in evolution to unicellular eukaryotes or even bacteria, where the domains appear to be involved in other regulatory functions, Cell-death systems in animals and plants share several conserved domains, in particular the family of apoptotic ATPases; this allows us to suggest a plausible, even if still incomplete, scenario for the evolution of apoptosis,

引用

页码：47 / 53

页数：7

共 53 条

[51] Retinoblastoma protein in growth suppression and death protection [J].