Secretion of the orgC gene product by Salmonella enterica serovar typhimurium

被引：12

作者：

Day, JB ^{[1
]}

Lee, CA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 11期

关键词：

D O I：

10.1128/IAI.71.11.6680-6685.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HilA activates the transcription of genes on Salmonella pathogenicity island 1 (SPI1), which encodes a type III secretion system (TTSS). Previous studies showed that transposon insertions in orgC, a gene located on SPI1, increase hil4 expression. We characterize the orgC gene product and show that it is secreted via the SPI1 TTSS. We propose a model whereby OrgC functions as a secreted repressor of the SPI1 virulence genes.

引用

页码：6680 / 6685

页数：6

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