Nramp1 phagocyte intracellular metal withdrawal defense

被引：147

作者：

Cellier, Mathieu F. ^{[1
]}

Courville, Pascal ^{[1
]}

Campion, Carole ^{[1
]}

机构：

[1] Inst Armand Frappier, INRS, Laval, PQ H7V 1B7, Canada

来源：

MICROBES AND INFECTION | 2007年 / 9卷 / 14-15期

基金：

加拿大自然科学与工程研究理事会;

关键词：

divalent cations; transport proteins; phagosomes;

D O I：

10.1016/j.micinf.2007.09.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural resistance-associated macrophage proteins (Nramp) are multispecific symporters facilitating proton-dependent import of divalent metals. Nramp1 restricts microbial access to essential micro-nutrients such as iron and manganese within professional phagosomes. Increased understanding of Nramp1 roles in human phagocytes will be useful for future therapeutic approaches against selected infectious and immune diseases. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1662 / 1670

页数：9

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