A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates

被引：16

作者：

Ruiz, J

Moreno, A

de Anta, MTJ

Vila, J

机构：

[1] Hosp Clin Barcelona, IDIBAPS, Microbiol Serv, E-08036 Barcelona, Spain

[2] Hosp Clin Barcelona, IDIBAPS, Ctr Salut Int, E-08036 Barcelona, Spain

[3] Hosp Clin Barcelona, IDIBAPS, Serv Malaties Infeccioses, E-08036 Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2005年 / 25卷 / 06期

关键词：

Campylobacter; resistance; moxifloxacin; levofloxacin; gyrA;

D O I：

10.1016/j.ijantimicag.2004.10.016

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The aim of this study was to compare different fluoroquinolones against Campylobacter spp., analysing the molecular mechanisms of resistance. Moxifloxacin exhibited the greatest activity of the quinolones tested, being active against isolates carrying a single mutation in the gyrA gene. High resistance levels to moxifloxacin were related to the presence of a double gyrA mutation. (c) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：542 / 545

页数：4

共 13 条

[1]

Allos BM, 2001, CLIN INFECT DIS, V32, P1201, DOI 10.1086/319760

[2] Single or double mutational alterations of GyrA associated with fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli [J].

Bachoual, R ;

Ouabdesselam, S ;

Mory, F ;

Lascols, C ;

Soussy, CJ ;

Tankovic, J .

MICROBIAL DRUG RESISTANCE, 2001, 7 (03) :257-261

[3] Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence [J].

Cole, ST ;

Brosch, R ;

Parkhill, J ;

Garnier, T ;

Churcher, C ;

Harris, D ;

Gordon, SV ;

Eiglmeier, K ;

Gas, S ;

Barry, CE ;

Tekaia, F ;

Badcock, K ;

Basham, D ;

Brown, D ;

Chillingworth, T ;

Connor, R ;

Davies, R ;

Devlin, K ;

Feltwell, T ;

Gentles, S ;

Hamlin, N ;

Holroyd, S ;

Hornby, T ;

Jagels, K ;

Krogh, A ;

McLean, J ;

Moule, S ;

Murphy, L ;

Oliver, K ;

Osborne, J ;

Quail, MA ;

Rajandream, MA ;

Rogers, J ;

Rutter, S ;

Seeger, K ;

Skelton, J ;

Squares, R ;

Squares, S ;

Sulston, JE ;

Taylor, K ;

Whitehead, S ;

Barrell, BG .

NATURE, 1998, 393 (6685) :537-+

[4] In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pump [J].

Luo, N ;

Sahin, O ;

Lin, J ;

Michel, LO ;

Zhang, QJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (01) :390-394

[5] Functional characterisation of mycobacterial DNA gyrase: an efficient decatenase [J].

Manjunatha, UH ;

Dalal, M ;

Chatterji, M ;

Radha, DR ;

Visweswariah, SS ;

Nagaraja, V .

NUCLEIC ACIDS RESEARCH, 2002, 30 (10) :2144-2153

[6]

*NAT COMM CLIN LAB, 2003, M7A6 NAT COMM CLIN L

[7] Selection and characterization of fluoroquinolone-resistant mutants of Campylobacter jejuni using enrofloxacin [J].

Payot, S ;

Cloeckaert, A ;

Chaslus-Dancla, E .

MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 2002, 8 (04) :335-343

[8] Increased resistance to quinolones in Campylobacter jejuni:: A genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates [J].

Ruiz, J ;

Goñi, P ;

Marco, F ;

Gallardo, F ;

Mirelis, B ;

De Anta, TJ ;

Vila, J .

MICROBIOLOGY AND IMMUNOLOGY, 1998, 42 (03) :223-226

[9] The complete genome sequence of the gastric pathogen Helicobacter pylori [J].

Tomb, JF ;

White, O ;

Kerlavage, AR ;

Clayton, RA ;

Sutton, GG ;

Fleischmann, RD ;

Ketchum, KA ;

Klenk, HP ;

Gill, S ;

Dougherty, BA ;

Nelson, K ;

Quackenbush, J ;

Zhou, LX ;

Kirkness, EF ;

Peterson, S ;

Loftus, B ;

Richardson, D ;

Dodson, R ;

Khalak, HG ;

Glodek, A ;

McKenney, K ;

Fitzegerald, LM ;

Lee, N ;

Adams, MD ;

Hickey, EK ;

Berg, DE ;

Gocayne, JD ;

Utterback, TR ;

Peterson, JD ;

Kelley, JM ;

Cotton, MD ;

Weldman, JM ;

Fujii, C ;

Bowman, C ;

Watthey, L ;

Wallin, E ;

Hayes, WS ;

Weidman, JM ;

Fujii, C ;

Borodovsky, M ;

Karp, PD ;

Smith, HO ;

Fraser, CM ;

Venter, JC .

NATURE, 1997, 388 (6642) :539-547

[10] Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli [J].

Vila, J ;

Ruiz, J ;

Goni, P ;

DeAnta, MTJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (02) :491-493

← 1 2 →