Resuscitation-promoting factors possess a lysozyme-like domain

被引：60

作者：

Cohen-Gonsaud, M

Keep, NH

Davies, AP

Ward, J

Henderson, B

Labesse, G

机构：

[1] Univ London Birkbeck Coll, Sch Crystallog, London WC1E 7HX, England

[2] Univ London Birkbeck Coll, BBRSC Ctr Struct Biol, London WC1E 7HX, England

[3] Royal Free & Univ Coll Med Sch, Dept Med Microbiol, London NW3 2PF, England

[4] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

[5] UCL, Eastman Dent Inst, Div Infect & Immun, London WC1X 8LD, England

[6] Univ Montpellier I, CNRS, UMR 5048, INSERM,U554,Ctr Biochim Struct, F-34060 Montpellier, France

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 01期

关键词：

D O I：

10.1016/j.tibs.2003.10.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The novel bacterial cytokine family - resuscitation-promoting factors (Rpfs) - share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs possess a lysozyme-like domain. The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs.

引用

页码：7 / 10

页数：4

共 29 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].