Cytotoxic T lymphocyte responses to Epstein-Barr virus

被引：60

作者：

Rickinson, AB

Lee, SP

Steven, NM

机构：

[1] CRC Institute for Cancer Studies, Clin. Res. Block, The Med. Sch., U., Birmingham

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(96)80036-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epstein-Barr virus induces a potent cytotoxic T lymphocyte response in man that is preferentially directed towards a particular subset of the virus latent cycle antigens; the immunodominance of these proteins, apparent in both primary and memory responses, may reflect some differential access to the HLA class I processing pathway. Effector cells recognizing these immunodominant antigens can reverse the growth of virus-induced lymphoproliferative lesions in immunosuppressed patients; however, responses to some of the subdominant latent proteins will be needed to target other virus-positive tumours.

引用

收藏

页码：492 / 497

页数：6

相关论文

共 44 条

[1] DOMINANT SELECTION OF AN INVARIANT T-CELL ANTIGEN RECEPTOR IN RESPONSE TO PERSISTENT INFECTION BY EPSTEIN-BARR-VIRUS [J].

ARGAET, VP ;

SCHMIDT, CW ;

BURROWS, SR ;

SILINS, SL ;

KURILLA, MG ;

DOOLAN, DL ;

SUHRBIER, A ;

MOSS, DJ ;

KIEFF, E ;

SCULLEY, TB ;

MISKO, IS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (06) :2335-2340

[2] Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway [J].

Biederer, T ;

Volkwein, C ;

Sommer, T .

EMBO JOURNAL, 1996, 15 (09) :2069-2076

[3] SPECIFIC CYTOTOXIC T-LYMPHOCYTES RECOGNIZE THE IMMEDIATE-EARLY TRANSACTIVATOR ZTA OF EPSTEIN-BARR-VIRUS [J].

BOGEDAIN, C ;

WOLF, H ;

MODROW, S ;

STUBER, G ;

JILG, W .

JOURNAL OF VIROLOGY, 1995, 69 (08) :4872-4879

[4] DIFFERENT HLA-B27 SUBTYPES PRESENT THE SAME IMMUNODOMINANT EPSTEIN-BARR-VIRUS PEPTIDE [J].

BROOKS, JM ;

MURRAY, RJ ;

THOMAS, WA ;

KURILLA, MG ;

RICKINSON, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) :879-887

[5] Unusually high frequency of Epstein-Barr virus genetic variants in Papua New Guinea that can escape cytotoxic T-cell recognition: Implications for virus evolution [J].

Burrows, JM ;

Burrows, SR ;

Poulsen, LM ;

Sculley, TB ;

Moss, DJ ;

Khanna, R .

JOURNAL OF VIROLOGY, 1996, 70 (04) :2490-2496

[6] 5 NEW CYTOTOXIC T-CELL EPITOPES IDENTIFIED WITHIN EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-3 [J].

BURROWS, SR ;

GARDNER, J ;

KHANNA, R ;

STEWARD, T ;

MOSS, DJ ;

RODDA, S ;

SUHRBIER, A .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :2489-2493

[7] AN EPSTEIN-BARR VIRUS-SPECIFIC CYTOTOXIC T-CELL EPITOPE IN EBV NUCLEAR ANTIGEN-3 (EBNA-3) [J].

BURROWS, SR ;

SCULLEY, TB ;

MISKO, IS ;

SCHMIDT, C ;

MOSS, DJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (01) :345-349

[8] T-CELL RECEPTOR REPERTOIRE FOR A VIRAL EPITOPE IN HUMANS IS DIVERSIFIED BY TOLERANCE TO A BACKGROUND MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN [J].

BURROWS, SR ;

SILINS, SL ;

MOSS, DJ ;

KHANNA, R ;

MISKO, IS ;

ARGAET, VP .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :1703-1715

[9] AN ALLORESPONSE IN HUMANS IS DOMINATED BY CYTOTOXIC T-LYMPHOCYTES (CTL) CROSS-REACTIVE WITH A SINGLE EPSTEIN-BARR-VIRUS CTL EPITOPE - IMPLICATIONS FOR GRAFT-VERSUS-HOST DISEASE [J].

BURROWS, SR ;

KHANNA, R ;

BURROWS, JM ;

MOSS, DJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (04) :1155-1161

[10]

CALLEN MFG, 1996, IN PRESS NAT MED

← 1 2 3 4 5 →