Uncertainty in the niches that maintain haematopoietic stem cells

被引：419

作者：

Kiel, Mark J.

Morrison, Sean J. ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Inst Life Sci, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Ctr Stem Cell Biol, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 04期

关键词：

D O I：

10.1038/nri2279

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain stem cells and regulate their maintenance. Cells at the interface of bone and the bone marrow (the endosteum) contribute to the creation of HSC niches. It remains uncertain whether this interface itself is a niche, or whether endosteal cells secrete factors that diffuse to nearby niches. Vascular and/or perivascular cells may also create niches as many HSCs are observed around sinusoidal blood vessels, and perivascular cells secrete factors that regulate HSC maintenance. Do endosteal and perivascular cells create distinct niches, or do they contribute to a common niche? We discuss a range of niche models consistent with recent evidence.

引用

收藏

页码：290 / 301

页数：12

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