Lipid rafts in T cell signalling and disease

被引：116

作者：

Jury, Elizabeth C. ^{[1
]}

Flores-Borja, Fabian ^{[1
]}

Kabouridis, Panagiotis S. ^{[2
]}

机构：

[1] UCL, Royal Free & Univ Coll Med Sch, Ctr Rheumatol, London W1P 4JF, England

[2] Barts & London Queen Marys Sch Med & Dent, Bone & Joint Res Unit, London EC1M 6BQ, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 05期

基金：

英国惠康基金;

关键词：

lipid rafts; T cell; lupus; autoimmunity; review;

D O I：

10.1016/j.semcdb.2007.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Lipid rafts is a blanket term used to describe distinct areas in the plasma membrane rich in certain lipids and proteins and which are thought to perform diverse functions. A large number of studies report on lipid rafts having a key role in receptor signalling and activation of lymphocytes. In T cells, lipid raft involvement was demonstrated in the early steps during T cell receptor (TCR) stimulation. Interestingly, recent evidence has shown that signalling in these domains differs in T cells isolated from patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Here, we discuss these findings and explore the potential of lipid rafts as targets for the development of a new class of agents to downmodulate immune responses and for the treatment of autoimmune diseases. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：608 / 615

页数：8

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