The CCR5 and CXCR4 coreceptors - Central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection

被引：348

作者：

Moore, JP

Kitchen, SG

Pugach, P

Zack, JA

机构：

[1] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, UCLA AIDS Inst, Dept Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, UCLA AIDS Inst, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2004年 / 20卷 / 01期

关键词：

D O I：

10.1089/088922204322749567

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this review, we will discuss what is known, what is suspected, and what still remains obscure about the central role played by coreceptor expression and usage in the transmission and pathogenic consequences of human immunodeficiency virus type 1 (HIV-1) infection. An emphasis will be on the HIV-1 phenotypic variants that are defined by their usage of the CCR5 or CXCR4 coreceptors, and how the different cellular tropism of these variants influences how and where HIV-1 replicates in vivo. We will also review what might happen when coreceptor antagonists are used clinically to treat HIV-1 infection.

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页码：111 / 126

页数：16

相关论文

共 232 条

[81] Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs [J].

Harouse, JM ;

Gettie, A ;

Tan, RCH ;

Blanchard, J ;

Cheng-Mayer, C .

SCIENCE, 1999, 284 (5415) :816-819

[82] CD8+ T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques [J].

Harouse, JM ;

Buckner, C ;

Gettie, A ;

Fuller, R ;

Bohm, R ;

Blanchard, J ;

Cheng-Mayer, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10977-10982

[83] The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection [J].

Haynes, BF ;

Markert, ML ;

Sempowski, GD ;

Patel, DD ;

Hale, LP .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :529-560

[84] T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART) [J].

Hazenberg, MD ;

Stuart, JWTC ;

Otto, SA ;

Borleffs, JCC ;

Boucher, CAB ;

de Boer, RJ ;

Miedema, F ;

Hamann, D .

BLOOD, 2000, 95 (01) :249-255

[85] T cell depletion in HIV-I infection:: how CD4+ T cells go out of stock [J].

Hazenberg, MD ;

Hamann, D ;

Schuitemaker, H ;

Miedema, F .

NATURE IMMUNOLOGY, 2000, 1 (04) :285-289

[86] Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers [J].

Hendrix, CW ;

Flexner, C ;

MacFarland, RT ;

Giandomenico, C ;

Fuchs, EJ ;

Redpath, E ;

Bridger, G ;

Henson, GW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (06) :1667-1673

[87] Stromal cell-derived factor 1/CXCR4 signaling is critical for early human T-cell development [J].

Hernández-López, C ;

Varas, A ;

Sacedón, R ;

Jiménez, E ;

Muñoz, JJ ;

Zapata, AG ;

Vicente, A .

BLOOD, 2002, 99 (02) :546-554

[88] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].

HO, DD ;

NEUMANN, AU ;

PERELSON, AS ;

CHEN, W ;

LEONARD, JM ;

MARKOWITZ, M .

NATURE, 1995, 373 (6510) :123-126

[89] The role of a mutant CCR5 allele in HIV-1 transmission and disease progression [J].

Huang, YX ;

Paxton, WA ;

Wolinsky, SM ;

Neumann, AU ;

Zhang, LQ ;

He, T ;

Kang, S ;

Ceradini, D ;

Jin, ZQ ;

Yazdanbakhsh, K ;

Kunstman, K ;

Erickson, D ;

Dragon, E ;

Landau, NR ;

Phair, J ;

Ho, DD ;

Koup, RA .

NATURE MEDICINE, 1996, 2 (11) :1240-1243

[90]

Husman AD, 1999, J IMMUNOL, V163, P4597

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