Cytokines and cardiovascular disease

被引：114

作者：

Mehra, VC

Ramgolam, VS

Bender, JR

机构：

[1] Yale Univ, Sch Med, Sect Cardiovasc Med, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06510 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2005年 / 78卷 / 04期

关键词：

atherosclerosis; inflammation; congestive heart failure; innate immunity; adaptive immunity;

D O I：

10.1189/jlb.0405182

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of cytokines in the pathogenesis of cardiovascular disease is increasingly evident since the identification of immune/inflammatory mechanisms in atherosclerosis and heart failure. In this review, we describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function. These include myocardial depressant effects of nitric oxide (NO) synthase-generated NO, as well as the biochemical effects of cytokine-stimulated arachidonic acid metabolites on cardiomyocytes. Cytokine influences on myocardial function are time-, concentration-, and subtype-specific. We provide a comprehensive review of these cytokine-mediated immune and inflammatory cascades implicated in the most common forms of cardiovascular disease.

引用

收藏

页码：805 / 818

页数：14

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