A genomewide survey of developmentally relevant genes in Ciona intestinalis -: III.: Genes for Fox, ETS, nuclear receptors and NFκB

被引：117

作者：

Yagi, K

Satou, Y ^{[1
]}

Mazet, F

Shimeld, SM

Degnan, B

Rokhsar, D

Levine, M

Kohara, Y

Satoh, N

机构：

[1] Kyoto Univ, Dept Zool, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan

[2] Univ Reading, Sch Anim & Microbial Sci, Reading RG6 6AJ, Berks, England

[3] Univ Queensland, Dept Zool & Entomol, Brisbane, Qld 4072, Australia

[4] US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA

[5] Univ Calif Berkeley, Dept Mol & Cellular Biol, Div Genet & Dev, Berkeley, CA 94720 USA

[6] Natl Inst Genet, Mishima, Shizuoka 4118540, Japan

来源：

DEVELOPMENT GENES AND EVOLUTION | 2003年 / 213卷 / 5-6期

基金：

日本学术振兴会;

关键词：

Ciona intestinalis; Fox; ETS; nuclear receptors; NF kappa B;

D O I：

10.1007/s00427-003-0322-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A survey against the draft genome sequence and the cDNA/EST database of Ciona intestinalis identified a number of genes encoding transcription factors regulating a variety of processes including development. In the present study, we describe almost complete sets of genes for Fox, ETS-domain transcription factors, nuclear receptors, and NFkappaB as well as other factors regulating NFkappaB activity, with their phylogenetic nature. Vertebrate Fox transcription factors are currently delineated into 17 subfamilies: FoxA to FoxQ. The present survey yielded 29 genes of this family in the Ciona genome, 24 of which were Ciona orthologues of known Fox genes. In addition, we found 15 ETS aenes, 17 nuclear receptor genes, and several NFkappaB signaling pathway genes in the Ciona genome. The number of Ciona genes in each family is much smaller than that of vertebrates, which represents a simplified feature of the ascidian genome. For example, humans have two NFkappaB genes, three Rel genes, and five NFAT genes, while Ciona has one gene for each family. The Ciona genome also contains smaller numbers of genes for the NFkappaB regulatory system, i.e. after the split of ascidians/vertebrates, vertebrates evolved a more complex NFkappaB system. The present results therefore provide molecular information for the investigation of complex developmental processes, and an insight into chordate evolution.

引用

页码：235 / 244

页数：10

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