Understanding the Structure and Function of the Immunological Synapse

被引：181

作者：

Dustin, Michael L. ^{[3
,4
]}

Chakraborty, Arup K. ^{[5
]}

Shaw, Andrey S. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA

[3] NYU, Program Mol Pathogenesis, Skirball Inst Biomol Med, New York, NY 10016 USA

[4] NYU, Dept Pathol, New York, NY 10016 USA

[5] MIT, Dept Chem Engn, Dept Chem, Div Biol Engn, Cambridge, MA 02139 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 10期

关键词：

T-CELL-RECEPTOR; MICROTUBULE-ORGANIZING CENTER; PROTEIN-KINASE-C; SUPRAMOLECULAR ACTIVATION CLUSTER; PLASMA-MEMBRANE MICRODOMAINS; DENDRITIC CELLS; IN-VIVO; PATTERN-FORMATION; SECRETORY DOMAIN; EPITHELIAL-CELLS;

D O I：

10.1101/cshperspect.a002311

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial. Here we review some of these current issues in the field: how the synapse is defined, its potential role in T-cell function, and our current understanding about how the synapse is formed.

引用

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