Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects

被引：19

作者：

Curtis, James ^{[1
,2
]}

Kopanitsa, Liliya ^{[1
,2
]}

Stebbings, Emma ^{[1
,2
]}

Speirs, Arran ^{[1
,2
]}

Ignatyeva, Olga ^{[3
,4
,5
]}

Balabanova, Yanina ^{[3
,4
,5
]}

Nikolayevskyy, Vladyslav ^{[4
,5
]}

Hoffner, Sven ^{[6
]}

Horstmann, Rolf ^{[7
]}

Drobniewski, Francis ^{[4
,5
]}

Nejentsev, Sergey ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Med, Cambridge CB2 2QQ, England

[2] Addenbrookes Hosp, Cambridge CB2 0QQ, England

[3] Samara Oblast TB Dispensary, Samara, Russia

[4] Univ London, Barts & London Sch Med, Hlth Protect Agcy, Natl Mycobacterium Reference Lab, London, England

[5] Univ London, Clin TB & HIV Grp, Inst Cell & Mol Sci, Barts & London Sch Med, London, England

[6] Swedish Inst Infect Dis Control, Dept Bacteriol, Solna, Sweden

[7] Bernhard Nocht Inst Trop Med, Dept Mol Med, D-20359 Hamburg, Germany

来源：

TUBERCULOSIS | 2011年 / 91卷 / 01期

基金：

英国惠康基金;

关键词：

Tuberculosis; Gene; SNP; Association; Heterozygosity; MYCOBACTERIUM-TUBERCULOSIS; SP110; GENE; IMMUNITY; SUSCEPTIBILITY; PATHOGENESIS; ZEBRAFISH; VARIANTS;

D O I：

10.1016/j.tube.2010.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoregulatory eicosanoids have been implicated in protection from mycobacterial infection in cell and animal models. Recently, a study of the zebrafish embryo demonstrated that mutants of the lta4h gene, which encodes the leukotriene A4 hydrolase (LTA4H) enzyme of the eicosanoid pathway, have hypersusceptibility to Mycobacterium marinum infection. It also reported that heterozygosity at the two single nucleotide polymorphisms rs1978331 and rs2660898 located in introns of the LTA4H gene, a human homologue of lta4h, is associated with protection from pulmonary tuberculosis. To replicate this association we genotyped six LTA4H gene polymorphisms in samples from 3703 pulmonary tuberculosis patients and 5412 healthy controls collected in Russia. We found no evidence of the protective effect of heterozygosity at the polymorphisms rs1978331 and rs2660898 (P = 0.29 and 0.49) and no association of the alleles of any of the six polymorphisms (P = 0.13-0.81). These results suggest that common polymorphisms in the LTA4H gene do not play any major role in susceptibility to clinical pulmonary tuberculosis. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：22 / 25

页数：4

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