Regulation of laminin and COUP-TF expression in extraembryonic endodermal cells

被引:32
作者
Murray, P [1 ]
Edgar, D [1 ]
机构
[1] Univ Liverpool, Dept Human Anat & Cell Biol, Liverpool L69 3GE, Merseyside, England
基金
英国医学研究理事会;
关键词
laminin; LAMB1; LAMC1; primitive endoderm; COUP-TF; basement membrane;
D O I
10.1016/S0925-4773(00)00554-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Laminin expression and the subsequent deposition of a basement membrane by primitive endoderm cells is necessary for early mammalian development. We demonstrate that the transcription factors COUP-TF I and II are up-regulated in primitive endoderm cells faster than LAMB1 and LAMC1. and that either COUP-TF is sufficient to induce expression of these laminin genes. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:213 / 215
页数:3
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