Epstein-Barr virus associated diffuse large B-cell lymphoma complicated by autoimmune hemolytic anemia and pure red cell aplasia

被引：24

作者：

Katayama, H ^{[1
]}

Takeuchi, M ^{[1
]}

Yoshino, T ^{[1
]}

Munemasa, M ^{[1
]}

Tada, A ^{[1
]}

Soda, R ^{[1
]}

Takahashi, K ^{[1
]}

机构：

[1] Natl Sanatorium Minami Okayama Hosp, Dept Internal Med, Okayama 7010304, Japan

来源：

LEUKEMIA & LYMPHOMA | 2001年 / 42卷 / 03期

关键词：

diffuse large B cell-lymphoma; Epstein-Barr virus; autoimmune haemolytic anemia; pure red cell aplasia;

D O I：

10.3109/10428190109064614

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 53-year old man with systemic lymphadenopathy and hepatosplenomegaly was diagnosed with diffuse large B cell-lymphoma after inguinal lymph node biopsy. Anemia was noted, direct and indirect Coombs tests were positive, and the haptoglobin level was low. However, the bone marrow aspirate revealed erythroid aplasia. Cc-existing autoimmune haemolytic anemia (AIHA) and pure red cell aplasia (PRCA) were diagnosed. In situ hybridization with Epstein-Barr virus (EBV) encoded small RNA (EBER) showed positive findings in lymphoma cells. Southern blot hybridization revealed immunoglobulin heavy chain gene rearrangement and a clonal EBV terminal repeat, indicating monoclonal proliferation of EBV in infected B cells. The patient was treated with CHOP, resulting in a complete remission (CR). AIHA and PRCA subsided after 3 courses of chemotherapy. In conclusion, this case demonstrates not only the association of B-cell lymphoma with autoimmune disorders but also the involvement of EBV in these conditions.

引用

页码：539 / 542

页数：4

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