The effects of egg-derived antibodies to glucosyltransferases on dental caries in rats

被引：36

作者：

Krüger, C

Pearson, SK

Kodama, Y

Smith, AV

Bowen, WH

Hammarström, L

机构：

[1] Huddinge Hosp, Karolinska Inst, Div Clin Immunol, SE-14186 Huddinge, Sweden

[2] Novum, Karolinska Inst, Ctr Oral Biol, Huddinge, Sweden

[3] Univ Rochester, Med Ctr, Ctr Oral Biol, Rochester, NY 14642 USA

[4] Ghen Cooperat, Immunol Res Inst, Gifu, Japan

来源：

CARIES RESEARCH | 2004年 / 38卷 / 01期

关键词：

chicken antibodies; glucosyltransferase(s); immunotherapy; Streptococcus mutans;

D O I：

10.1159/000073914

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The role of Streptococcus mutans in the development of dental caries is well recognized. Important virulence factors include the glucosyltransferases (gtf), essential for production of glucans. We evaluated the anticariogenic effects of orally administered chicken anti-cell-associated (CA) Gtf antibodies in desalivated rats. The animals were infected with S. mutans MT8148R and treated with chicken anti-CA-Gtf egg yolk antibodies (IgY) or nonimmune egg yolk powder. Smooth surface lesions were significantly lower in the anti-CA-Gtf-treated group in comparison to the control groups. Sulcal surface caries was also decreased and of less severity. Our study suggests that chicken anti-CA-Gtf antibodies may have promise as a prophylaxis for high caries risk patients.

引用

页码：9 / 14

页数：6

共 35 条

[21] Production, characterization, and application of monoclonal antibodies which distinguish four glucosyltransferases from Streptococcus sobrinus [J].