Actin polymerization: Riding the wave

被引:42
作者
Smith, LG
Li, R
机构
[1] Univ Calif San Diego, Sect Cell & Dev Biol, La Jolla, CA 92093 USA
[2] Harvard Univ, Dept Cell Biol, Boston, MA 02115 USA
关键词
D O I
10.1016/j.cub.2004.01.016
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
WAVE/SCAR has long been known to activate the actin-nucleating Arp2/3 complex in a Rac-dependent manner. Recent biochemical and genetic studies have revealed important roles for four WAVE-associated proteins in regulating WAVE function.
引用
收藏
页码:R109 / R111
页数:3
相关论文
共 19 条
[1]   SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development [J].
Bear, JE ;
Rawls, JF ;
Saxe, CL .
JOURNAL OF CELL BIOLOGY, 1998, 142 (05) :1325-1335
[2]   PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium [J].
Blagg, SL ;
Stewart, M ;
Sambles, C ;
Insall, RH .
CURRENT BIOLOGY, 2003, 13 (17) :1480-1487
[3]   Kette regulates actin dynamics and genetically interacts with Wave and Wasp [J].
Bogdan, S ;
Klämbt, C .
DEVELOPMENT, 2003, 130 (18) :4427-4437
[4]  
DAIZ Z, 1995, GENE DEV, V9, P2569
[5]   Arp2/3 and 'The Shape of things to come' [J].
Deeks, MJ ;
Hussey, PJ .
CURRENT OPINION IN PLANT BIOLOGY, 2003, 6 (06) :561-567
[6]   Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck [J].
Eden, S ;
Rohatgi, R ;
Podtelejnikov, AV ;
Mann, M ;
Kirschner, MW .
NATURE, 2002, 418 (6899) :790-793
[7]   A small, novel protein highly conserved in plants and animals promotes the polarized growth and division of maize leaf epidermal cells [J].
Frank, MJ ;
Smith, LG .
CURRENT BIOLOGY, 2002, 12 (10) :849-853
[8]  
Hummel T, 2000, GENE DEV, V14, P863
[9]   Molecular cloning of p125(Nap1), a protein that associates with an SH3 domain of Nck [J].
Kitamura, T ;
Kitamura, Y ;
Yonezawa, K ;
Totty, NF ;
Gout, I ;
Hara, K ;
Waterfield, MD ;
Sakaue, M ;
Ogawa, W ;
Kasuga, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 219 (02) :509-514
[10]   p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase [J].
Kobayashi, K ;
Kuroda, S ;
Fukata, M ;
Nakamura, T ;
Nagase, T ;
Nomura, N ;
Matsuura, Y ;
Yoshida-Kubomura, N ;
Iwamatsu, A ;
Kaibuchi, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (01) :291-295