The role of water in protein DNA interactions

被引：159

作者：

Schwabe, JWR

机构：

[1] Gene Expression Laboratory, Salk Inst. Biol. Studs., 10010 N. T., San Diego

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(97)80016-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is becoming well accepted that water plays an important role in both the specificity and affinity of protein-DNA interactions. Recently, a combination of structural, biochemical and thermodynamic techniques has particularly enhanced our understanding of the role of water in complexes between DNA and three different proteins: the trp repressor; the homeodomain; and the glucocorticoid receptor DNA-binding domain.

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页码：126 / 134

页数：9

相关论文

共 70 条

[1] RECOGNITION OF A DNA OPERATOR BY THE REPRESSOR OF PHAGE-434 - A VIEW AT HIGH-RESOLUTION [J].

AGGARWAL, AK ;

RODGERS, DW ;

DROTTAR, M ;

PTASHNE, M ;

HARRISON, SC .

SCIENCE, 1988, 242 (4880) :899-907

[2] STRUCTURE OF THE REPRESSOR OPERATOR COMPLEX OF BACTERIOPHAGE 434 [J].

ANDERSON, JE ;

PTASHNE, M ;

HARRISON, SC .

NATURE, 1987, 326 (6116) :846-852

[3] A RECIPE FOR SPECIFICITY [J].

ARBUCKLE, ND ;

LUISI, B .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (05) :341-346

[4] MUTANT TRP REPRESSORS WITH NEW DNA-BINDING SPECIFICITIES [J].

BASS, S ;

SORRELLS, V ;

YOUDERIAN, P .

SCIENCE, 1988, 242 (4876) :240-245

[5] HYDRATION OF DNA - TAKE 2 [J].

BERMAN, HM .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1994, 4 (03) :345-350

[6] DETERMINATION OF THE NUCLEAR-MAGNETIC-RESONANCE SOLUTION STRUCTURE OF AN ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX [J].

BILLETER, M ;

QIAN, YQ ;

OTTING, G ;

MULLER, M ;

GEHRING, W ;

WUTHRICH, K .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 234 (04) :1084-1094

[7] Hydration and DNA recognition by homeodomains [J].

Billeter, M ;

Guntert, P ;

Luginbuhl, P ;

Wuthrich, K .

CELL, 1996, 85 (07) :1057-1065

[8] Hydration water molecules seen by NMR and by X-ray crystallography [J].

Billeter, M .

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 1995, 27 :635-645

[9]

Bishop TC, 1996, PROTEINS, V24, P115

[10]

BLOKZIJL W, 1993, ANGEW CHEM INT EDIT, V32, P1545, DOI 10.1002/anie.199315451

← 1 2 3 4 5 6 7 →