The role of water in protein DNA interactions

被引：159

作者：

Schwabe, JWR

机构：

[1] Gene Expression Laboratory, Salk Inst. Biol. Studs., 10010 N. T., San Diego

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(97)80016-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is becoming well accepted that water plays an important role in both the specificity and affinity of protein-DNA interactions. Recently, a combination of structural, biochemical and thermodynamic techniques has particularly enhanced our understanding of the role of water in complexes between DNA and three different proteins: the trp repressor; the homeodomain; and the glucocorticoid receptor DNA-binding domain.

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页码：126 / 134

页数：9

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