One-pot organocatalytic direct asymmetric synthesis of γ-amino alcohol derivatives

被引：91

作者：

Córdova, A ^{[1
]}

机构：

[1] Scripps Res Inst, La Jolla, CA 92037 USA

来源：

SYNLETT | 2003年 / 11期

关键词：

asymmetric synthesis; asymmetric catalysis; Mannich reactions; aldehydes; imines;

D O I：

10.1055/s-2003-41423

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This report describes the unprecedented use of unmodified aldehydes as donors in catalytic three component one-Pot asymmetric Mannich reactions. The Mannich-type reactions were also readily performed for the first time with both in situ generated and preformed N-PMP protected aromatic aldimines. The prolinecatalyzed reactions provided an efficient and very mild entry to either enantiomer of gamma-amino alcohol derivatives in high yield and stereoselectivity.

引用

页码：1651 / 1654

页数：4

共 52 条

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