MicroRNAs in the pathogeny of chronic lymphocytic leukaemia

被引：42

作者：

Nicoloso, Milena S.

Kipps, Thomas J.

Croce, Carlo M.

Calin, George A.

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[3] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 139卷 / 05期

关键词：

microRNAs; chronic lymphocytic leukaemia; BCL2; mutations;

D O I：

10.1111/j.1365-2141.2007.06868.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRNAs) have been linked to the initiation and progression of chronic lymphocytic leukaemia (CLL). The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein-coding genes. Recent studies have shown that miRNAs are the main candidates for the elusive class of CLL predisposing genes. These discoveries could be exploited for the development of useful markers for diagnosis and prognosis, as well as for the development of new RNA-based cancer therapies.

引用

页码：709 / 716

页数：8

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