Cell cycle in mouse development

被引：119

作者：

Ciemerych, MA

Sicinski, P ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[3] Univ Warsaw, Fac Biol, Inst Zool, Dept Embryol, PL-02096 Warsaw, Poland

来源：

ONCOGENE | 2005年 / 24卷 / 17期

关键词：

mouse embryo; development; cell cycle;

D O I：

10.1038/sj.onc.1208608

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mice likely represent the most- studied mammalian organism, except for humans. Genetic engineering in embryonic stem cells has allowed derivation of mouse strains lacking particular cell cycle proteins. Analyses of these mutant mice, and cells derived from them, facilitated the studies of the functions of cell cycle apparatus at the organismal and cellular levels. In this review, we give some background about the cell cycle progression during mouse development. We next discuss some insights about in vivo functions of the cell cycle proteins, gleaned from mouse knockout experiments. Our text is meant to provide examples of the recent experiments, rather than to supply an extensive and complete list.

引用

收藏

页码：2877 / 2898

页数：22

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