JAM family and related proteins in leukocyte migration (Vestweber series)

被引:86
作者
Bradfield, Paul F.
Nourshargh, Sussan
Aurrand-Lions, Michel
Imhof, Beat A.
机构
[1] Univ Geneva, Ctr Med, Dept Pathol & Immunol, CH-1211 Geneva 4, Switzerland
[2] Imperial Coll London, Cardiovasc Med Unit, Natl Heart & Lung Inst, Fac Med, London, England
关键词
endothelium; leukocyte; transmigration; inflammation;
D O I
10.1161/ATVBAHA.107.147694
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Exploring the role of junctional adhesion molecules (JAMs) has proven to be varied and controversial. The purpose of this review is to discuss the new and exciting roles of these IgSF molecules and how they have evolved to contribute to diverse functions from development to inflammation. In particular, recent research has focused on JAM subfamily members JAM-A, -B, and -C with newly described roles in leukocyte trafficking during inflammation and angiogenesis. However, research on all JAM family members has demonstrated recurring themes with striking similarities in the many diverse processes they are now known to regulate.
引用
收藏
页码:2104 / 2112
页数:9
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