共 11 条
Orthotopic liver transplantation for Byler's disease
被引:7
作者:
Torri, E
Lucianetti, A
Pinelli, D
Corno, V
Guizzetti, M
Maldini, G
Zambelli, M
Bertani, A
Melzi, ML
Alberti, D
Doffria, E
Giovanelli, M
Torre, G
Spada, M
Gridelli, B
Colledan, M
机构:
[1] Osped Riuniti Bergamo, Ctr Trapianti Fegato & Polmoni, I-24128 Bergamo, Italy
[2] Univ Palermo, Ctr Med, ISMETT, Palermo, Italy
关键词:
D O I:
10.1016/j.transproceed.2005.01.041
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
In this study we analyzed the features of 12 patients who underwent liver transplantation for progressive familial intrahepatic cholestasis (Byler's disease [BD]) in view of the technical features of the OLTx, incidence and type of complications, need for retransplantation, as well as patient and graft survivals. BD was the indication in 12 patients of median age 1.32 years and median weight 10 kg. Median follow-up was 670 days. Major surgical complications requiring reintervention occurred in three patients. No thrombosis of the hepatic artery was observed. Infections with positive blood cultures were diagnosed in four patients. One patient had a biliary anastomotic stenosis successfully treated by percutaneous techniques. Four patients had episodes of acute rejection treated with steroids. Two patients were retransplanted, both of whom died in the early postoperative period due to hepatic vein thrombosis and venoenteric fistula. The actuarial patient and graft survival was 83% at 1 year and 83% at 5 years. Split-liver grafts represent an excellent organ supply for these patients, achieving good results with no mortality on the waiting list.
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页码:1149 / 1150
页数:2
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