Cardiac arrhythmias: the possible role of the renin-angiotensin system

被引：37

作者：

De Mello, WC ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Pharmacol, San Juan, PR 00936 USA

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2001年 / 79卷 / 2-3期

关键词：

cardiac arrhythmias; renin angiotensin system;

D O I：

10.1007/s001090100195

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Activation of the renin-angiotensin system during the process of heart failure may predispose the heart to reentrant malignant arrhythmias by reducing the cell coupling and conduction velocity. Here I discuss the possible role of the renin-angiotensin system on the modulation of cell coupling and impulse propagation with consequent generation of reentrant rhythms. Particular emphasis is given to the effects of angiotensin II on the electrical properties of the failing heart and the beneficial effects of angiotensin-converting enzyme inhibitors and angiotensin II AT1 receptor blockade.

引用

页码：103 / 108

页数：6

共 51 条

[41] CHRONIC ADMINISTRATION OF ANGIOTENSIN-II RECEPTOR ANTAGONIST, TCV-116, IN CARDIOMYOPATHIC HAMSTERS [J].

NAKAMURA, F ;

NAGANO, M ;

KOBAYASHI, R ;

HIGAKI, J ;

MIKAMI, H ;

KAWAGUCHI, N ;

ONISHI, S ;

OGIHARA, T .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1994, 267 (06) :H2297-H2304

[42]

ROGERS TB, 1986, J PHARMACOL EXP THER, V236, P438

[43] COMPARATIVE EFFECTS OF CHRONIC ANGIOTENSIN-CONVERTING ENZYME-INHIBITION AND ANGIOTENSIN-II TYPE-1 RECEPTOR BLOCKADE ON CARDIAC REMODELING AFTER MYOCARDIAL-INFARCTION IN THE RAT [J].

SCHIEFFER, B ;

WIRGER, A ;

MEYBRUNN, M ;

SEITZ, S ;

HOLTZ, J ;

RIEDE, UN ;

DREXLER, H .

CIRCULATION, 1994, 89 (05) :2273-2282

[44]

SHAW R, 1998, DEV CARDIOVASC MED, P125

[45]

Sosinsky G, 2000, CURR TOP MEMBR, V49, P1

[46] PHOSPHORYLATION OF LIVER GAP JUNCTION PROTEIN BY PROTEIN-KINASE-C [J].

TAKEDA, A ;

HASHIMOTO, E ;

YAMAMURA, H ;

SHIMAZU, T .

FEBS LETTERS, 1987, 210 (02) :169-172

[47] Antagonistic effects of losartan on thromboxane A2-receptors in human isolated gastroepiploic artery and saphenous vein [J].

Tripodi, F ;

Stanke-Labesque, F ;

Devillier, P ;

Chavanon, O ;

Sessa, C ;

Bessard, G .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1999, 34 (05) :734-740

[48] STRUCTURAL AND ELECTROPHYSIOLOGICAL CHANGES IN THE EPICARDIAL BORDER ZONE OF CANINE MYOCARDIAL INFARCTS DURING INFARCT HEALING [J].

URSELL, PC ;

GARDNER, PI ;

ALBALA, A ;

FENOGLIO, JJ ;

WIT, AL .

CIRCULATION RESEARCH, 1985, 56 (03) :436-451

[49] TOWARD AN UNDERSTANDING OF THE MOLECULAR-BASIS OF CARDIOMYOPATHIES [J].

WEISMAN, HF ;

WEISFELDT, ML .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1987, 10 (05) :1135-1138

[50]

Wit A.L., 1990, CARDIAC ELECTROPHYSI, P603

← 1 2 3 4 5 6 →