Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors

被引：35

作者：

Meagher, KL ^{[1
]}

Mewshaw, RE ^{[1
]}

Evrard, DA ^{[1
]}

Zhou, P ^{[1
]}

Smith, DL ^{[1
]}

Scerni, R ^{[1
]}

Spangler, T ^{[1
]}

Abulhawa, S ^{[1
]}

Shi, XJ ^{[1
]}

Schechter, LE ^{[1
]}

Andree, TH ^{[1
]}

机构：

[1] Wyeth Ayerst Res Labs, Global Chem Sci & Neurosci Dept, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(01)00334-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of indolylcyclohexylamines possessing potent and selective serotonin reuptake inhibition is reported. The most interesting compounds proved to have subnanomolar 5-HT transporter activity, and exhibited moderate 5-HT1A affinity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1885 / 1888

页数：4

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