Endogenous and exogenous ARC in serum withdrawal mediated PC12 cell apoptosis: a new pro-apoptotic role for ARC

被引：19

作者：

Dowds, TA ^{[1
]}

Sabban, EL ^{[1
]}

机构：

[1] New York Med Coll, Dept Biochem & Mol Biol, Valhalla, NY 10595 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2001年 / 8卷 / 06期

关键词：

ARC; caspase-2; PC12; cells; serum withdrawal; aggregation; apoptosis;

D O I：

10.1038/sj.cdd.4400855

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of ARC (Apoptosis Repressor with Caspase Recruitment Domain) in PC12 cell serum withdrawal driven apoptosis was studied. A progressive and massive increase in ARC protein occurs during serum withdrawal that correlates with declining survival and processing of caspase-2, previously shown to associate with ARC.(1) This accumulation of ARC occurs in a transcriptional and translational independent manner. Additionally, ARC is localized exclusively in the nucleus of PC12 cells. Furthermore, transfection of PC12 cells with hARC-Flag promotes death and fails to protect the cells from apoptosis by serum withdrawal. Therefore, ARC functions in a pro-apoptotic manner in PC12 cell serum withdrawal induced apoptosis.

引用

页码：640 / 648

页数：9

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